Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients

University of Sao Paulo

Status: Terminated

Conditions: Diabetes Mellitus, Type 1; Periodontal Pocket; Periodontal Diseases

Treatments: Procedure: Antimicrobial photodynamic therapy; Procedure: Scaling root planing

Study type: Interventional

Funder types: Other

Identifiers

NCT03102892

BauruSchoolDentistryPDTDM1

Details and patient eligibility

About

The aim of this study is to evaluate adjuvant effect of antimicrobial photodynamic therapy in periodontal treatment and salivary status of type 1 diabetes patients.

Full description

Diabetes Mellitus is a risk factor for periodontal disease increasing its prevalence, extension and severity. Periodontal disease is considered the sixth complication of diabetes. There is a global epidemic of diabetes, including an increase of type 1 diabetes incidence in younger patients. Adjuvant treatments to scaling and root planing as antimicrobial photodynamic therapy show improved clinical outcomes. Thus, the aim of this randomized clinical trial is to evaluate adjuvant effect of antimicrobial photodynamic therapy in periodontal treatment and salivary status of type 1 diabetes patients.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnose of Type 1 diabetes mellitus
• Age between 18 to 65 years old
• Presence of at least one tooth for hemiarch
• Moderate and severe periodontal disease

Exclusion criteria

• Type 2 diabetes mellitus
• Total edentulism
• Smokers
• Pregnancy
• Systemic diseases as other endocrine diseases and blood diseases
• Use of drugs that alter periodontal tissue as phenytoin and cyclosporine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Scaling Root Planing

Active Comparator group

Description:

Treatment by scaling and root planing. Repetition after 7 and 14 days.

Treatment:

Procedure: Scaling root planing

Antimicrobial Photodynamic Therapy

Experimental group

Description:

Scaling and root planing and Antimicrobial photodynamic therapy with red laser (658 nm, 0.1 Watts, 2229 J/cm², 10s per point) and methylene blue dye (10mg/ml). Repetition after 7 and 14 days.

Treatment:

Procedure: Scaling root planing

Procedure: Antimicrobial photodynamic therapy