Antimicrobial Stewardship Reduces MDRO Isolates in Critically Ill Patients

Jianfeng Xie

Status: Completed

Conditions: Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT02128399

MDRO

Details and patient eligibility

About

Antimicrobial exposure is known to reduce the selection for various drug-resistant organisms. Numerous studies have demonstrated the association between antimicrobial use and MDR bacteria detection. However, to the investigators knowledge, there is few data to support the concept that reducing antibiotic use actually leads to improvements in antibiotic susceptibilities. Moreover, antimicrobial stewardship was demonstrated to reduce MDRO and was strongly recommended in clinics. As the investigators know, antimicrobial overuse, which occurs commonly in China, induces a severe antibacterial resistance. China's Ministry of Health (MOH) has established a policy about the antimicrobial stewardship. To date, the investigators do not have published documentation the effects of this policy on multidrug-resistant organism (MDRO) in critically ill patients.

Enrollment: 978 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients hospitalized in the ICU

Exclusion criteria

• Patients who were readmitted to the ICU during a single hospital stay

Trial design

978 participants in 1 patient group

patients before and after intervetion