Antioxidant Effect of Aged Garlic Extract

Hiroshima University

Status: Completed

Conditions: Heavy Smoker or Non-smoker

Treatments: Dietary Supplement: Aged garlic extract; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02019368

eki-843

Details and patient eligibility

About

This is a randomized, double-blind, placebo controlled, crossover study to determine the antioxidant effect of aged garlic extract. This study will also compare the oxidative status in heavy smokers with that in non-smokers.

Enrollment: 60 patients

Sex: Male

Ages: 40 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Smoking (at least 20 cigarettes per day) or non-smoking (more than 20 years)

Exclusion criteria

• Under medication for chronic disease
• Garlic allergy
• Engaging in vigorous exercise
• Taking drugs or functional food that may possess antioxidant property
• Participation in any clinical trial within 90 days of the commencement of the trial
• Renal or hepatic dysfunction
• Heart disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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60 participants in 3 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Smoker subjects take 6 capsules once a day for 4 weeks.

Treatment:

Dietary Supplement: Placebo

Aged garlic extract

Experimental group

Description:

Smoker subjects take 1.5 g of aged garlic extract in 6 capsules once a day for 4 weeks.

Treatment:

Dietary Supplement: Aged garlic extract

Non-smoker

No Intervention group

Description:

Oxidative status in non-smoker