Antioxidant Functions of Lipoic Acid

National Institutes of Health (NIH)

Status and phase: Completed; Phase 2

Conditions: Hypercholesterolemia

Treatments: Drug: lipoic acid

Study type: Interventional

Funder types: NIH

Identifiers

NCT00065624

R21AT001062-01A2

Details and patient eligibility

About

The goal of this study is to determine whether a short treatment with lipoic acid, an antioxidant used in the treatment of diabetic neuropathy, improves blood vessel reactivity and decreases oxidant stress in persons with elevated blood cholesterol.

Full description

As per Brief Summary

Sex: All

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Lipid criteria for inclusion are a plasma LDL between 160 and 190 mg/dl (total cholesterol usually 240-285 mg/dl)
• Less than 2 coronary risk factors, and already on a cholesterol-lowering diet.

Exclusion criteria

• Overt or clinical atherosclerosis
• Diabetes
• Currently taking cholesterol-lowering medication.
• Subjects with other lipid disorders
• Subjects taking supplemental lipoic acid, vitamin C, or vitamin E.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind