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Antioxidants Vitamins and Muscle Damage

E

European University

Status

Completed

Conditions

Oxidative Stress

Treatments

Dietary Supplement: Dietary Supplement: Vitamin C and vitamin E
Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT05127928
CIPI/20/209-part2

Details and patient eligibility

About

Determine if acute supplementation with antioxidant vitamins (vitamin C and vitamin E) influences the muscle damage and fatigue caused after an acute session of eccentric training.

Full description

A randomized, single-blind, placebo-control parallel trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria.

Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided. Participants will be divided in to groups and will performance one resistance exercise sessions. Prior to exercise, one group will intake supplementation VitC (1000 mg) + VitE (235 mg) and the other supplementation with placebo.

The following sequence will be performed in each session: 1) baseline assessment (analysis of the composition body, blood draw and parameters of performance) prior to exercise session ; 2) administration of vitamin or placebo supplementation 2 hours before exercise session ; 3) post-exercise assessments (blood biomarkers and performance parameters) immediately after the session and after 24 hours. DOMS will also be assessed 48 h and 72 h after training. The training session implemented will be designed by a Sport Scientific

Enrollment

18 patients

Sex

All

Ages

18 to 33 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy
  • Physically active

Exclusion criteria

  • Injuries
  • Supplementation or drugs
  • Smokers

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

18 participants in 2 patient groups, including a placebo group

Supplementation
Experimental group
Description:
Vitamin C and Vitamin E before exercise
Treatment:
Dietary Supplement: Dietary Supplement: Vitamin C and vitamin E
Placebo
Placebo Comparator group
Description:
Placebo before exercise
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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