Antioxidants vs. Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve

Fertiaguerrevere

Status: Completed

Conditions: Ovarian Reserve

Treatments: Procedure: blood rich plasma platelets; Dietary Supplement: Antioxidant therapy

Study type: Interventional

Funder types: Industry

Identifiers

NCT03621683

J298384255

Details and patient eligibility

About

Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received antioxidant therapy daily for 3 months. Results are noted and analysed.

Both groups represent patients with procedures already ongoing, and with diagnosed poor or depleted ovarian reserve.

The analysis has been made to compare the efficacy of both procedures.

Full description

The bioestimulation group received a blood rich platelet therapy monthly for three months, with a technique developed by the laboratory. The second group of antioxidants received a combination of antioxidants monthly for three months. Both groups were compared to assess the results in terms of ovarian response (number of astral follicles, AMH levels, FSH, LH), and egg quality, embryo development, implantation rate, and successful pregnancy with healthy live birth.

Enrollment: 78 patients

Sex: Female

Ages: 38 to 46 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 38 and 46 years
• FSH> 12 mIU
• Estradiol > 100 pg/ml
• AMH < 0.8 ng/mL

Exclusion criteria

• Pelvic inflammatory syndrome
• vaginal pathologies
• known history of hyperandrogenism
• diagnosed platelet disorders as adhesion
• aggregation
• disorder of thromboxane synthesis.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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78 participants in 2 patient groups

ovarian bio-stimulation

Experimental group

Description:

Intervention: ovarian bio-stimulation: blood rich plasma platelets

Treatment:

Dietary Supplement: Antioxidant therapy

Procedure: blood rich plasma platelets

Antioxidant therapy

Active Comparator group

Description:

Intervention: antioxidants: Q10, DHEA, Vitamin E, Vitamin C, omega 3

Treatment:

Dietary Supplement: Antioxidant therapy

Procedure: blood rich plasma platelets