Antiphospholipid Antibodies and Early Severe Preeclampsia.

Saint Thomas Hospital (HST)

Status: Unknown

Conditions: Antiphospholipid Syndrome; Severe Preeclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT01538121

MHST2012-01A

Details and patient eligibility

About

The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and obstetric complications (miscarriages, stillbirths). Since 1999 the Sapporo Criteria for Antiphospholipid Syndrome diagnosis includes the development of severe preeclampsia before 34 weeks of gestation, but this was done without solid evidence of a relation between the two. Our study will try to add information to this particular point.

Enrollment: 310 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Gestational age between 24-34 weeks
• Diagnosis of severe preeclampsia

Exclusion criteria

• Known antiphospholipid syndrome.
• Known presence of antiphospholipid antibodies.
• Patients with systemic lupus erythematosus.

Trial design

310 participants in 2 patient groups

Cases-Early Severe Preeclampsia

Description:

Patients with severe preeclampsia before 34 weeks of gestation

Controls

Description:

Patients with normal pregnancies at term.