Antithrombin III and Post-liver Transplantation Acute Kidney Injury

Asan Medical Center

Status: Completed

Conditions: Liver Transplantation and Antithrombin

Treatments: Drug: Antithrombin III

Study type: Observational

Funder types: Other

Identifiers

NCT04912193

2019-1699

Details and patient eligibility

About

The reno-protective effect of Antithrombin III (ATIII) has been well-studied in various animal studies; however, little is known about the effect of ATIII on kidney function in patients undergoing liver transplantation (LT). This study aimed to determine the association between preoperative ATIII level and postoperative acute kidney injury (AKI) after LT (post-LT AKI).

Enrollment: 2,395 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who underwent either living- or deceased-donor LT (LDLT, DDLT) from January 2010 to January 2018

Exclusion criteria

• patients who underwent re-transplantation
• patients who were previously diagnosed with end-stage renal disease or Chronic kidney disease
• patients who were being treated with continuous renal replacement therapy
• preoperative or postoperative Antithrombin III levels were not available

Trial design

2,395 participants in 2 patient groups

antithrombin III < 50 %

Description:

preoperative antithrombin III levels \<50%

Treatment:

Drug: Antithrombin III

Antithrombin III ≥ 50 %

Description:

preoperative antithrombin III levels ≥ 50 %