Aortic Cross Clamping Time, and Postoperative Respiratory Function

Assiut University

Status: Completed

Conditions: Bypass Complication; Respiratory Complication

Treatments: Procedure: aortic cross clamping

Study type: Interventional

Funder types: Other

Identifiers

NCT03072784

IRB00009915

Details and patient eligibility

About

Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.

Full description

Cardiac surgery usually is done under cardiopulmonary bypass. As the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. Of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. Follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.

Enrollment: 53 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients
• elective open heart surgery

Exclusion criteria

• Patients with myocardial ischemia or previous infarction
• low ejection fraction <30%
• history of AF
• implanted pacemaker
• uncontrolled hypertension
• renal impairment (creatinine >1.8 mg/dl)
• hepatic dysfunction
• insulin dependent diabetes
• chronic pulmonary disease

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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53 participants in 2 patient groups

group S

Active Comparator group

Description:

short time \<90 m aortic cross clamping

Treatment:

Procedure: aortic cross clamping

group L

Active Comparator group

Description:

\> 90 minutes aortic cross clamping

Treatment:

Procedure: aortic cross clamping