Aortic Distensibility (FAMRI)

Mayo Clinic

Status: Completed

Conditions: Abdominal Aortic Aneurysm

Study type: Observational

Funder types: Other

Identifiers

NCT00587977

1994-04

2A3360

FAMRI 2

Details and patient eligibility

About

Can software be developed to automatically aid in the measurement of abdominal aortic aneurysms, and is there a way to predict future rupture or growth of abdominal aortic aneurysms.

Full description

Hypothesis: ECG-gated multidetector CT and ECG-gated Dual Source CT can be used to create multiple volumetric datasets of the abdominal aorta over the time period of the cardiac cycle, allowing for direct and regional calculations of abdominal aortic distensibility over the entire volume of the abdominal aorta, providing insight into risk of abdominal aortic aneurysm rupture and early large vessel stiffness.

Enrollment: 67 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• AAA must be at least 3 cm to a maximum 4.9cm cross-sectional diameter.
• BMI 31 or less.
• Creatinine results <2.0 and within six months prior to scan.
• US patients must have only normal creatinine (0.9 to 1.4) for one year before study visit.
• Patients who are originally scheduled for US, who are then subsequently rolled in this study, will have only a ultrasound scan as followup after the initial CTA.

Exclusion criteria

• Creatinine > 2.0.
• Creatinine <0.9 or >1.4 for those who are scheduled for US.
• Atrial fibrillation or other arrythmia.
• Known AAA greater than 5 cm in size.
• Allergy to contrast dye.

Trial design

67 participants in 3 patient groups

1

Description:

Aortic aneurysm repair

2

Description:

Aortic aneurysm growth

3

Description:

Aortic aneurysm growth stable.