Aortic Stenosis With COmplex PCI (ASCOP) Features Retrospective Registry on Contemporary Management and Outcomes

Niguarda Hospital

Status: Completed

Conditions: Angioplasty, Balloon, Coronary; Coronary Artery Disease; Transcatheter Aortic Valve Replacement; Aortic Valve Stenosis

Treatments: Procedure: Transcatheter aortic valve intervention (TAVI) and percutaneous coronary intervention (PCI)

Study type: Observational

Funder types: Other

Identifiers

NCT05750927

723-1412202

Details and patient eligibility

About

To describe the prevalence and clinical features of patients with severe aortic stenosis undergoing TAVI and concomitant clinically indicated, complex and/or high-risk PCI

Full description

The aims of this study are:

• to describe the prevalence and clinical features of patients with severe aortic stenosis undergoing TAVI and concomitant clinically indicated, complex and/or high-risk PCI
• to depict the different possible strategies that are currently employed in this context and to retrospectively analyze outcomes
• to investigate predictors of better outcomes

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

1. Severe, symptomatic aortic stenosis with an indication to TAVI

2. Concomitant, stable CAD with an indication to complex PCI, as anticipated by angiography, defined as follows (one or more features)

   1. Left-main (LM) CAD or proximal left anterior descending (LAD) / left circumflex (LCx) lesions requiring LM-PCI
   2. Three-vessel disease
   3. Last remaining vessel
   4. Bifurcation PCI (proximal bifurcation)
   5. Severely calcified lesions requiring calcium plaque modification (rotational/orbital atherectomy, intravascular lithotripsy, scoring or cutting balloon)
   6. Lesion length > 30 mm
   7. Severely depressed Left ventricular function requiring mechanical circulatory support (intra-aortic balloon pump - IABP, Impella, Extracorporeal Membrane Oxygenation - ECMO

Trial design

100 participants in 1 patient group

ASCoP (severe Aortic Stenosis with Complex PCI features)

Description:

Subjects with severe aortic stenosis undergoing transcatheter aortic valve intervention and with concomitant, complex coronary artery disease with a clinical indication for percutaneous coronary intervention

Treatment:

Procedure: Transcatheter aortic valve intervention (TAVI) and percutaneous coronary intervention (PCI)