Aortic Stiffness and Distensibility as Predictor to Severity of Coronary Artery Disease

Assiut University

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Diagnostic Test: echocardiography and coronary angiography

Study type: Observational

Funder types: Other

Identifiers

NCT03615963

Aortic stiffness

Details and patient eligibility

About

Assess the relationship of Aortic root distensibility and stiffness with the extent of coronary artery disease as assessed by SYNTAX score compared to a matched cohort of patients with normal coronary angiography

Full description

Cardiovascular disease leading cause of death, resulting in a number of annually deceased people higher than from any other. The great incidence of cardiovascular diseases in the world spurred the search for new solutions to enable an early detection of pathological processes The early detection based in multi-parameters of pathological condition is the key to the patient survival .The arterial stiffness is the first vessels modification, responsible for several pathological processes, which can lead to cardiovascular diseases.

The normal aging process is associated with an increase in vascular stiffness which is accelerated by atherosclerosis, hypertension, and diabetes mellitus. Several studies have revealed that increased aortic stiffness is a risk factor for cardiovascular diseases and also is a predictor of cardiovascular morbidity and mortality.

Interest in arterial stiffness waned in the early 1900s with the advent of the sphygmomanometer, which offered a quantitative measure of blood pressure and risk prediction .

Another factor is Aortic distensibility which is a measurement of vascular elasticity, and reflects the stiffness of the aorta . Aortic distensibility is markedly decreased in patients with known coronary artery disease . and is inversely proportional to the severity of Coronary artery disease .

Two-dimensional and tissue Doppler imaging derived parameters of ascending aorta have been found to be abnormal, indicating increased Aortic stiffness and impaired Aortic distensibility in subjects with coronary artery disease, hypertension, and diabetes mellitus. However, the direct correlation of Aortic stiffness with Coronary artery disease is hard to examine as most of these patients are old and have comorbidities such as hypertension, So Investigation of these parameters should be done in patients who are normotensive as most of these patients do not have confounding factors that increase Aortic stiffness.

Although the relationship between Aortic distensibility and Aortic stiffness and atherosclerosis is well known , the possible relation between them and the extent and complexity of coronary artery disease. as assessed using SYNTAX score has not been clearly determined yet.

The SYNTAX score is a lesion-based angiographic scoring system originally devised to grade the complexity of coronary artery disease.

. It is related to adverse cardiovascular events and predicts mortality and morbidity in patients with coronary artery disease.

Enrollment: 150 patients

Sex: All

Ages: Under 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients suspected to have coronary artery disease

Exclusion criteria

• -Hypertension( SBP>140mmhg or DBP>90mmhg)
• Previous coronary stenting
• Previous CABG
• Renal diseases.
• Decompensated liver disease.
• Connective tissue diseases.
• Aortic valve disease ( more than mild aortic stenosis or regurgitation)

Trial design

150 participants in 2 patient groups

normal

Description:

patient complains of anginal chest pain but coronary angiography is normal

Treatment:

Diagnostic Test: echocardiography and coronary angiography

coronary artery disease

Description:

patient complains of chest pain with coronary angiography showing atherosclerotic plaques causing luminal obstruction

Treatment:

Diagnostic Test: echocardiography and coronary angiography