Aortoiliac Stenosis in Kidney Transplantation (TASC)

Erasmus University

Status: Completed

Conditions: Aorto-Iliac Arterial Stenosis; Kidney Transplant Failure; Peripheral Arterial Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06020534

KT TASC

Details and patient eligibility

About

The impact of aortoiliac stenosis on kidney transplant patients remains unclear. This study aims to investigate the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis.

Full description

Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD). Unfortunately, not all ESRD patients are eligible for kidney transplantation. Aortoiliac stenosis, an increasingly common type of peripheral arterial disease in ESRD patients, is considered as relative contra-indication for kidney transplantation. There are several reasons for concern, such as the complexity of the vascular anastomosis and inferior life expectancy. Consequently, it is still debated whether patients with aortoiliac stenosis would benefit from kidney transplantation.

This study aimed to supplement current literature on the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis. To achieve this, all patients undergoing kidney transplantation in Erasmus Medical Center between January 2010 and December 2020 were enrolled, and propensity score matching was used to minimize confounding factors. Additionally, long-term graft function was investigated to evaluate the impact of stenosis on graft function.

Enrollment: 655 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent kidney transplantation in the Erasmus Medical Center between January 2010 and December 2020

Exclusion criteria

• Patients who were under 18 years at transplantation
• Patients who underwent combined organ transplantation
• Patients who had no follow-up

Trial design

655 participants in 3 patient groups

No-stenosis group

Description:

Patients who had no pre-existing aortoiliac stenosis before kidney transplantation.

TASC A/B stenosis

Description:

Patients who had TASC A or B aortoiliac stenosis before kidney transplantation.

TASC C/D stenosis

Description:

Patients who had TASC C or D aortoiliac stenosis before kidney transplantation.