APA and PAS Training for Gait Initiation in Parkinson's Disease

C

Chang Gung University

Status

Enrolling

Conditions

Parkinson Disease

Treatments

Procedure: Paired associative stimulation
Other: Weight shift training and APA feedback

Study type

Interventional

Funder types

Other

Identifiers

NCT06363071
202000495A3

Details and patient eligibility

About

Our research focused on understanding the interplay between brain excitability and balance function in patients with Parkinson's disease (PD), alongside evaluating effective physical therapy methods. It highlights the prevalence of non-motor disorders and cognitive impairments among PD patients, including balance and postural issues, cognitive function decline, and gait instability. Additionally, it notes that PD patients exhibit abnormal electrophysiological responses, indicating altered central excitability.

Full description

Research on Brain Excitability and Balance Function Performance in Patients with Parkinson's Disease and Related Physical Therapy Methods Research indicates that non-motor disorders and cognitive impairments are prevalent in most patients with Parkinson's disease. These include balance issues, postural instability, impaired cognitive functions like working memory and executive functions, and gait instability. Additionally, electrophysiological phenomena in Parkinson's disease patients reveal abnormal central excitatory and inhibitory responses compared to healthy individuals. This experiment seeks to investigate the link between motor performance and brain excitability in patients with Parkinson's disease. Previous studies suggest that associative electrical stimulation, used to regulate sensorimotor information integration, can enhance brain excitability in both healthy individuals and those with Parkinson's disease. However, the optimal parameters for this stimulation remain uncertain. Furthermore, balance exercise training can improve motor performance in Parkinson's disease patients. This study aims to determine if various designs of associative electrical stimulation parameters can help these patients achieve optimal brain excitability regulation. The combined approach of this stimulation and balance exercise training aims to maintain and improve the patients' functional performance, thereby enhancing the safety of their daily activities.

Enrollment

100 estimated patients

Sex

All

Ages

20+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Health subjects:

Exclusion Criteria:

  • Musculoskeletal injuries on legs.
  • Osteoporosis.

PD subjects:

Inclusion Criteria:

- Clinical diagnosis of Parkinson disease.

Exclusion Criteria:

  • Musculoskeletal injuries on legs
  • Osteoporosis.
  • Any peripheral or central nervous system injury or disease patients.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

100 participants in 5 patient groups

Stage 1:Healthy people
Experimental group
Description:
To establish PAS baseline and reliability.
Treatment:
Procedure: Paired associative stimulation
Stage 2:PD people
Experimental group
Description:
To establish stage 3 training protocol.
Treatment:
Procedure: Paired associative stimulation
Stage 3:PD people
No Intervention group
Description:
Control group.
Stage 3: PD APA training group
Experimental group
Description:
Weight shift training and APA feedback.
Treatment:
Other: Weight shift training and APA feedback
Stage 3:PD PAS group
Experimental group
Description:
Using PAS to regulate brain plasticity
Treatment:
Procedure: Paired associative stimulation

Trial contacts and locations

1

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Central trial contact

Ya-Ju Chang, PhD

Data sourced from clinicaltrials.gov

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