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Apathy, defined as a quantitative reduction of voluntary, goal-directed behaviours (GDB), is a core component of negative symptoms. It has been suggested that the physiopathology of apathy is not a single entity but may be multiple, depending on which specific process or macrofunction is disrupted during completion of GDB. In line with this notion, Levy and Dubois proposed dividing apathic syndromes into three subtypes of disrupted processing: 'a-motivation', 'cognitive inertia', and 'uncoupling'. In schizophrenia, apathy has been associated with executive dysfunction, functional impairment and poor outcome. However, the neurobiological underpinnings of apathy in schizophrenia are poorly understood.
Primary objective: confirm that chronic schizophrenic patients are apathic compared to healthy volunteers
Secondary objectives:
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Inclusion Criteria (healthy volunteers):
Exclusion Criteria (healthy volunteers):
Inclusion Criteria (schizophrenic patients):
Exclusion Criteria (schizophrenic patients):
60 participants in 2 patient groups
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Central trial contact
Richard LEVY, MD/PHD
Data sourced from clinicaltrials.gov
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