Apathy in Tourette Syndrome and Changes in Quality of Life

University of Florida

Status: Completed

Conditions: Tourette Syndrome; Apathy

Treatments: Other: Gilles de la Tourette Syndrome Quality Of Life scale; Other: Studies Depression Scale for Children (CES-DC); Other: Children's Motivation Scale; Other: Demographic Data; Other: Yale Global Tic Severity Scale (YGTSS)

Study type: Observational

Funder types: Other

Identifiers

NCT02765178

IRB201500989

Details and patient eligibility

About

Tourette syndrome is a complex neuropsychological disorder with both motor and vocal tics associated with multiple psychological co-morbidities. Apathy has not been widely studied in patients with Tourette syndrome. Apathy can result in decrease in self-care and disease control. In this study investigators will compare the occurrence of apathy in the adolescent Tourette syndrome population (at the UF center for movement disorders and Neurorestoration) to an age and gender matched control population. Investigators will also assess the role of commonly used medications in the Tourette population (neuroleptics and selective serotonin receptor inhibitors) in the occurrence of apathy.

Full description

Tourette syndrome(TS) is a complex neuropsychological disorder with both motor and vocal tics associated with multiple psychological co-morbidities. The most common co-morbidities include obsessive compulsive disorder (OCD), attention deficit and hyperactivity disorder (ADHD) and depression. Apathy has not been extensively studied in the Tourette syndrome population. Apathy is currently defined as reduced motivation, with symptoms in at least two of three domains of reduced initiative, reduced interest and/or reduced emotional responsiveness. A study assessed the prevalence of apathy in multiple movement disorders and reported that apathy is much more common in disorders associated with slowed movements like Parkinson disease while less common in disorders with increased movements like Huntington disease and Tourette syndrome in adults. However, no apathy studies in adolescent patients with Tourette syndrome are published. Disengagement from treatment may affect health outcomes in other disease states. Apathy has significant effects on the quality of life and health outcomes in many patients. Apathy can be a direct manifestation of the neuropsychological process (intrinsic to the disease) or can be secondary to medication side effects most notably anti-dopaminergic agents and some reports of selective serotonin receptor inhibitors (SSRI). Further attention to the prevalence and impact of apathy in the adolescent Tourette syndrome population is needed to explore if this may be a factor influencing TS management and ultimately Quality of life (QOL). Multiple psychotropic medications are used in the management of tics as well as the psychological co-morbidities. How these medications affect apathy prevalence in Tourette syndrome patients is not known.

Enrollment: 38 patients

Sex: All

Ages: 12 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis: Tourette syndrome
• Age: 12-16 years
• Followed at the CMDNR

Exclusion criteria

• History of cerebral palsy or traumatic brain injury

Trial design

38 participants in 2 patient groups

Patients with Tourette Syndrome

Description:

The primary caregiver will be asked to fill the Children's motivation Scale. Other measures will be collected including a clinician filled Yale Global Tic Severity Scale (YGTSS) - severity score, Center for Epidemiological Studies Depression Scale for Children (CES-DC) and Gilles de la Tourette Syndrome Quality Of Life scale (GTS-QOL). Demographic data will also be collected for each study patient. Demographic data will also be collected for each study patient.

Treatment:

Other: Studies Depression Scale for Children (CES-DC)

Other: Demographic Data

Other: Children's Motivation Scale

Other: Yale Global Tic Severity Scale (YGTSS)

Other: Gilles de la Tourette Syndrome Quality Of Life scale

Patients with Diabetes type 1

Description:

The primary caregiver will be asked to fill the Children's motivation Scale. Demographic data will also be collected for each study patient.

Treatment:

Other: Children's Motivation Scale