Apatinib and Etoposide in Patients With Platinum Resistant or Refractory Ovarian Cancer

Sun Yat-sen University

Status and phase: Completed; Phase 2

Conditions: Ovarian Cancer

Treatments: Drug: Etoposide; Drug: Apatinib

Study type: Interventional

Funder types: Other

Identifiers

NCT02867956

B2016-020-01

Details and patient eligibility

About

The purpose of the study is to evaluate the efficacy and toxicity of apatinib in patients with platinum resistant or refractory ovarian cancer when combined with etoposide.

Full description

Ovarian cancer is the leading cause of death for patients with gynecologic malignancies. In most cases, the disease is diagnosed at an advanced stage and approximately 75% of patients will eventually experience disease recurrence. However, the overall response rates of second-line chemotherapy for recurrent ovarian cancer are only 20-27%. Therefore, it is important to seek alternative agent that can improve the outcome. Apatinib is a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor and it has been approved for the treatment of advanced gastric cancer. The preclinical studies suggest apatinib may be effective in other cancers such as ovarian cancer. Therefore, the purpose of this study is to test the efficacy and safety of the study drug apatinib when combined with a standard treatment, etoposide, for patients with platinum resistant or refractory ovarian cancer.

Enrollment: 35 estimated patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically or pathologically confirmed diagnosis of epithelial carcinoma of the ovary.

• Platinum resistant ovarian cancer (defined as relapsing within 6 months after the last administration of platinum-based chemotherapy) OR platinum refractory ovarian cancer (defined as progressing while on a platinum-based chemotherapy)

• At least treated with one line of platinum-based chemotherapy

• Female, age ≥18 years and ≤70 years, signed informed consent.

• Eastern Cooperative Oncology Group (ECOG) performance status 0-2

• Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 version

• Patients must have a life expectancy of at least 3 months.

• Patients must have adequate organ function as defined by the following criteria:

  • White blood cell count ≥ 3 x 10^9/L, Absolute neutrophil count (ANC) (≥ 1.5 x 10^9/L), Hemoglobin of ≥ 80 g/L, Platelets ≥ 70 x 10^9/L
  • Total bilirubin ≤ 1 x upper limit of normal (ULN), AST and ALT ≤ 2 x ULN
  • Serum creatinine ≤ 1 x ULN

Exclusion criteria

• Had prior exposure to apatinib or has known allegies to any of the excipients.
• History of myocardial infarction, or unstable angina, or New York Heart Association (NYHA) Grade III-IV within 6 months prior to Day 1.
• Patients with QT interval prolongation
• Serious, non-healing wound, active ulcer, bowel obstruction.
• History of abdominal fistula or gastrointestinal perforation within 28 days prior to Day 1
• Evidence of bleeding diathesis or coagulopathy
• Inadequately controlled hypertension
• Major surgical procedure within 28 days prior to Day 1
• Symptomatic central nervous system (CNS) metastasis

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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35 participants in 1 patient group

Apatinib + Etoposide

Experimental group

Description:

Apatinib 500mg daily, po, and it should be continued until disease progression or intolerable toxicity or patients withdrawal of consent. Etoposide 50mg daily, po, day 1 to day 14, repeat every 21 days for 6 cycles.

Treatment:

Drug: Apatinib

Drug: Etoposide