Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)

Aristotle University Of Thessaloniki

Status

Completed

Conditions

Diabetes Mellitus Type 2

Insulin Resistance

Obesity

Study type

Observational

Funder types

Other

Identifiers

NCT01121172

10012010

Details and patient eligibility

About

The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.

So far apelin has been reported to be involved in the pathophysiology of various heart diseases such as cardiomyopathies and heart failure. According to recent reports in adults apelin seems to be associated with impaired glucose metabolism, particularly in newly diagnosed diabetes type 2 patients. Obesity is associated with insulin resistance and compensatory hyperinsulinemia leading to diabetes mellitus type 2 even in youngsters. The researchers will try to investigate the role of this new adipokine in order to early detect and to prevent similar entities in childhood obesity.

Enrollment

180 patients

Sex

All

Ages

2 to 16 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria