ApoE Genotyping Analysis in Patients with Suspected Non-haemorrhagic Amyloid Angiopathy (CAA-WMH-ApoE)

Centre Hospitalier Universitaire de Nīmes

Status: Not yet enrolling

Conditions: Amyloid Angiopathy

Study type: Observational

Funder types: Other

Identifiers

NCT06809062

LOCAL/2024/DR-04

Details and patient eligibility

About

Ischaemic microangiopathic features have recently been incorporated into the criteria for cerebral amyloid angiopathy (CAA).

ApoE genotyping (presence of the E4 allele) is routinely used to help determine the aetiology of a haemorrhagic microangiopathy found on MRI.

Chronic ischaemic disease in CAA is characterised by the presence of :

• multispot pattern on the FLAIR sequence
• severe periventricular FLAIR hypersignals with posterior predominance

The main aim of this study was therefore to analyse the frequency of the presence of one (or two) E4 allele(s) on ApoE genotyping in patients with suspected CAA based on ischaemic MRI involvement with a typical radiological pattern.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with ischaemic stroke (from causes other than CAA, as CAA is not a frequent cause of ischaemic stroke) with associated stigmata of microangiopathy on MRI that may suggest associated CAA.
• Patients treated at Nîmes University Hospital

Exclusion criteria

• Patient refusing to participate

Trial design

100 participants in 1 patient group

ischaemic microangiopathy

Description:

The study is aimed at patients with manifestations related to a vascular accident visible on MRI.