Apomorphine Effects on Experimental Pain

Rambam Health Care Campus

Status and phase: Completed; Early Phase 1

Conditions: Healthy

Treatments: Drug: Apomorphine

Study type: Interventional

Funder types: Other

Identifiers

NCT01744964

0078-09-RBM

Details and patient eligibility

About

The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within the dopamine transporter gene.

Full description

Healthy volunteers (n=105) participated in this randomized double-blind, placebo-controlled, cross-over trial. Heat pain threshold and intensity, cold pain threshold, and the response to tonic cold pain (latency, intensity, and tolerance) were evaluated before and for up to 120 min after the administration of 1.5 mg apomorphine/placebo. A polymorphism (DAT-1) within the dopamine transporter gene (SLC6A3) was investigated.

Enrollment: 105 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy and free from chronic pain of any type did not use any medications other than oral contraceptives were able to understand the purpose and instructions of the study.

Exclusion criteria

• any type of medical or painful condition use of medications or recreational drugs pregnancy.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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105 participants in 2 patient groups, including a placebo group

Saline

Placebo Comparator group

Description:

Assessment of experimental pain models before and after treatment

Treatment:

Drug: Apomorphine

Apomorphine

Active Comparator group

Description:

Assessment of experimental pain models before and after treatment

Treatment:

Drug: Apomorphine