Apoptic Biomarkers of Periodontal Disease

University of Michigan

Status: Completed

Conditions: Periodontitis

Treatments: Other: collection of gingival crevicular fluid

Study type: Observational

Funder types: Other

Identifiers

NCT00569075

2004-04

Details and patient eligibility

About

The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated with cell death will be isolated from gum pockets of diseased and healthy patients and evaluated.

Full description

Early detection of the progression of periodontitis is difficult because it typically relies on comparisons of clinical measurements made with a calibrated probe and nonstandardized radiographs over time. Both methods detect periodontal breakdown only after it has occurred. Therefore, considerable emphasis has been placed on identifying more specific and sensitive methods to diagnose and detect periodontal disease progression. The overall goal of this project is to determine whether specific apoptosis-associated proteins, specifically fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults over age of 18
• Healthy or diagnosis of periodontitis

Exclusion criteria

• Active treatment with anti-inflammatory agents such as NSAIDs or steroids and pregnant females

Trial design

60 participants in 2 patient groups

High Risk

Description:

High risk disease prone population

Treatment:

Other: collection of gingival crevicular fluid

Low Risk

Description:

Low risk disease population

Treatment:

Other: collection of gingival crevicular fluid