Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.

Zekai Tahir Burak Women's Health Research and Education Hospital

Status: Unknown

Conditions: Pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT02192177

M30 Intrahepatic cholestasis

Details and patient eligibility

About

Intrahepatic cholestasis of pregnancy is a disease specific to pregnancy period; especially late second and third trimester. We aimed to investigate the role of apoptosis in etiopathogenesis of obstetric cholestasis.

Full description

M30 (caspases cleaved Cytokeratin-18 (CK-18) fragment) is a specific apoptosis marker. We aimed to use it to evaluate the apoptotic process.

Enrollment: 50 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Late second or third trimester of pregnancy.

Exclusion criteria

• Foreknown systemic diseases, multiple pregnancy, smoking cigarettes.

Trial design

50 participants in 2 patient groups

Group 1

Description:

Pregnant subjects diagnosed with obstetric cholestasis who didn't have any foreknown systemic disease.

Group 2

Description:

entirely healthy pregnant subjects, the control group.