Apparent Diffusion Coefficient as a Prognostic Biomarker in Cervical Cancer

Institute of Cancer Research, United Kingdom

Status: Completed

Conditions: Cancer

Treatments: Procedure: Magnetic Resonance Imaging using an endovaginal receiver coil

Study type: Observational

Funder types: Other

Identifiers

NCT01937533

13/EE/0198 CCR3938

Details and patient eligibility

About

This study aims to develop the technique of Diffusion-Weighted Magnetic Resonance Imaging(DW-MRI)for the assessment of stage 1 cervical cancers. An endovaginal receiver coil has been designed and developed at the Institute of Cancer Research and Royal Marsden NHS Foundation Trust for use at high field strengths(3T). This will be used to evaluate if DW-MRI at 3T can be used to differentiate different histological characteristics within whole tumours and so determine if the technique could be of prognostic value.

The study hypothesis is that this technique will be able to differentiate tumours with histological features known to be associated with poor prognosis (tumour type, grade and lymphovascular space invasion).

Enrollment: 236 patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients with presumed early stage cervical cancer being considered for curative surgery

Exclusion criteria

• Ferromagnetic metal implants
• claustrophobia (MRI incompatibility)

Trial design

236 participants in 1 patient group

Cervical Cancer

Description:

Patients with presumed early cervical cancer being considered for curative surgery

Treatment:

Procedure: Magnetic Resonance Imaging using an endovaginal receiver coil