Appearance of Far Peripheral Retina in Normal Eyes by Ultra-widefield Fluorescein Angiography

Sun Yat-sen University

Status: Completed

Conditions: Normal Eyes; Peripheral Retina

Study type: Observational

Funder types: Other

Identifiers

NCT02856139

2016036

Details and patient eligibility

About

PURPOSE: To characterize the appearance of the far peripheral retina of normal eyes using ultra-widefield fluorescein angiography (UWFA).

DESIGN: Prospective observational case series. METHODS: This study enrolled normal eyes with best corrected visual acuity ≥ 20/20, refractive error < 3.00D, and without visible retinal pathologic changes under a slit lamp-based condensing lens. The far peripheral retina was detected by UWFA. Ciliary body thickness (CBT) at 3 mm (CBT1) and 2 mm (CBT2) posterior to the scleral spur was measured by ultrasound biomicroscopy.

Full description

PURPOSE: To characterize the appearance of the far peripheral retina of normal eyes using ultra-widefield fluorescein angiography (UWFA).

DESIGN: Prospective observational case series. METHODS: This study enrolled normal eyes with best corrected visual acuity ≥ 20/20, refractive error < 3.00D, and without visible retinal pathologic changes under a slit lamp-based condensing lens. Demographic and clinical data such as age, sex, and reasons for undergoing FA were collected. The far peripheral retina was detected by UWFA. The fundal fields obtained using the Heidelberg ultra-widefield lens in a single shot and in montage images were compared with those acquired using the Heidelberg conventional 55° lens. The signs at the peripheral retina detected by UWFA were described and grouped. Ciliary body thickness (CBT) at 3 mm (CBT1) and 2 mm (CBT2) posterior to the scleral spur was measured by ultrasound biomicroscopy.

Enrollment: 61 patients

Sex: All

Ages: Under 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• best corrected visual acuity ≥ 20/20
• refractive error < 3.00D
• without visible retinal pathologic changes under a slit lamp-based condensing lens

Exclusion criteria

• history of ocular surgery
• presence of ocular or systemic diseases
• opacity of refractive media, which interfered with the peripheral retina image quality

Trial design

61 participants in 3 patient groups

1 (MB- and VL-)

Description:

without mottled fluorescent band (MB) and vascular leakage (VL)

2 (MB+ and VL-)

Description:

with mottled fluorescent band (MB), without vascular leakage (VL)

3 (MB-/+ and VL+)

Description:

with or without mottled fluorescent band (MB), with vascular leakage (VL)