Appetite Regulation in Children With Failure to Thrive

Lena Kirchner Brahe

Status: Completed

Conditions: Failure to Thrive

Study type: Observational

Funder types: Other

Identifiers

NCT02647580

M229

Details and patient eligibility

About

Failure to thrive (FTT) is an expression for inadequate growth in the early childhood and thus, a sign of undernutrition. This study will include children with FTT, and compare with existing data from children with normal and excessive growth.

The overall aim of this study is to explore whether 1) children who develop FTT with no organic explanation differ from healthy normal weight and overweight children in their basal level of appetite-regulating hormones and 2) if inadequate, normal and excessive growth in children can be partly predicted by variation in their gut microbiome and metabolome.

Enrollment: 45 patients

Sex: All

Ages: 12 to 36 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with failure to thrive
• Weight for height > 1.9 SD below the median by use of the WHO Child Growth Standards
• Age between 12-36 months

Exclusion criteria

• Cancer
• Inflammatory bowel disease
• Celiac disease
• Immunodeficiency
• Other somatic disease that can explain the growth failure