Application and Clinical Evaluation of Longitudinal Chromatic Aberration Technique in Ophthalmology

Capital Medical University

Status: Completed

Conditions: Longitudinal Chromatic Aberration; Blue Light Defocus Manipulation

Treatments: Behavioral: blue light defocus and blue light filtering

Study type: Interventional

Funder types: Other

Identifiers

NCT06449976

BeijingTH-202405

Details and patient eligibility

About

Our study aims to delve into the effects of shifting the focal point of blue light from video or text displayed on a terminal screen forward on the axial length of the eye, ocular blood flow, visual fatigue, and visual function, that is, its relationship with Video Display Terminal (VDT) syndrome and myopia. By examining the decoding ability of the adult subjects' retina to the clarity of the signal, we will attempt to develop a novel, non-invasive strategy to curb the elongation of the eyeball associated with myopia. Concurrently, we will also focus on the pathophysiological mechanisms underlying VDT syndrome and explore its potential link to the progression of myopia, providing new scientific evidence for the prevention and treatment of this ocular condition. This research is expected to provide robust support for addressing the global issue of myopia and the health challenges posed by VDT syndrome. Ultimately, by integrating global eye health issues with the challenges brought about by VDT syndrome, we will propose intervention and prevention strategies, offering new insights for the advancement of ophthalmology and public health sectors, thereby promoting visual acuity and ocular health for the population.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Adult population, regardless of gender
2. Refractive error is less than or equal to -2.5D and both eyes achieve corrected visual acuity of 0.8 or higher.
3. Normal intraocular pressure with no organic pathology.
4. No apparent symptoms of dry eye.
5. Willing to cooperate to complete all the tests.
6. Voluntarily signing the informed consent form.

Exclusion criteria

1. Individuals with strabismus and amblyopia exist.
2. Suffering from congenital eye conditions such as congenital cataracts or congenital retinal diseases.
3. Those who have undergone intraocular surgery (such as cataract removal, intraocular lens implantation, etc.).
4. Individuals with refractive media opacity (such as corneal lesions, lens opacity, etc.).
5. Abnormal intraocular pressure (IOP) (IOP < 10 mmHg or IOP > 21 mmHg, or a bilateral IOP difference of ≥5 mmHg).
6. Only one eye meets the inclusion criteria.
7. Active corneal infections such as bacterial, fungal, viral, or other acute or chronic anterior segment inflammations.
8. Currently using medications that may lead to dry eye or affect vision and corneal curvature.
9. Other ocular conditions, such as dacryocystitis, eyelid disorders and abnormalities, abnormal intraocular pressure, and glaucoma.
10. Unable to undergo regular eye examinations.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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21 participants in 4 patient groups

Blue Light 0D Defocus Group

Experimental group

Description:

This is the group that performs visual evoked tasks using videos and texts that are not defocused in the blue channel. In this group, the impact of standard video modes on the axial length of the eye, refractive fatigue, and visual function is assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Treatment:

Behavioral: blue light defocus and blue light filtering

Blue Light 1D Defocus Group

Experimental group

Description:

Group using blue channel defocused 1D videos and texts for visual evoked tasks. Participants will engage in a 50-minute visual evoked task using videos and texts processed with 1D blue channel. The impact of standard video mode on axial length of the eye, refractive labor, and visual function will be assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Treatment:

Behavioral: blue light defocus and blue light filtering

Blue Light 2D Defocus Group

Experimental group

Description:

The group uses blue channel defocused 2D videos and texts for visual evoked tasks. Participants will undergo a 50-minute visual evoked task using videos and texts processed with the 2D blue channel. The effects of standard video mode on the eye's axial length, refractive labor, and visual function are assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Treatment:

Behavioral: blue light defocus and blue light filtering

Blue Light 1D Defocus with Partial Filtration Group

Experimental group

Description:

The group uses videos and texts processed with the blue channel 1D defocus and 30% blue light filtering for visual evoked tasks. Participants will engage in a 50-minute visual evoked task using videos and texts that have been processed with the 1D blue channel and partially filtered for blue light. The impact of the standard video mode on the eye's axial length, refractive labor, and visual function is evaluated, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Treatment:

Behavioral: blue light defocus and blue light filtering