Application of Amide Proton Transfer-Weighted Imaging in Predicting Pathological Complete Response After Neoadjuvant Therapy of Rectal Cancer

Sun Yat-sen University

Status: Enrolling

Conditions: Rectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT06719414

2024ZSLYEC-552

Details and patient eligibility

About

The goal of this observational study is to learn about the amide proton transfer-weighted imaging for rectal cancer response assessment after neoadjuvant therapy. The main question it aims to answer is:

• Does amide proton transfer-weighted imaging predict the cancer response before surgery? Participants will underwent amide proton transfer-weighted imaging as part of their regular MRI examination.

Enrollment: 320 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Locally advanced rectal cancer(cT3-4, or cN+), resectable, histologically confirmed rectal adenocarcinoma
• Received neoadjuvant therapy before surgery
• Complete radical resection of rectal cancer and postoperative pathological examination
• Informed consent and signed the informed consent form

Exclusion criteria

• Poor image quality, such as severe artifacts
• Complicated with intestinal obstruction, intestinal perforation and other cases requiring surgical treatment
• The interval between preoperative MRI and surgery was more than 2 weeks
• Prior treatment for rectal cancer
• History of other malignant tumors
• Patients who cannot undergo MRI examination due to contraindications or relative contraindications
• Patients were lost to follow-up or voluntarily withdrew from the study due to adverse reactions or other reasons