Application of an Electronic Nose in the Early Detection of ASpergillosis (AENEAS)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status: Completed

Conditions: Pulmonary Invasive Aspergillosis

Study type: Observational

Funder types: Other

Identifiers

NCT01395446

28062009

Details and patient eligibility

About

The purpose of this study is to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls.

Enrollment: 52 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients that

1. are 18 years of age or older
2. will undergo treatment for a hematological malignancy expected to result in grade 4 neutropenia (according to CTCAE 3.0, i.e. <0.5 x 109 neutrophils/L) of prolonged duration (i.e., more than 7 days), e.g. hematopoietic stem cell transplantation or induction/consolidation treatment for acute myeloid leukaemia
3. have given written informed consent

Exclusion criteria

1. a previously diagnosed invasive mycosis
2. the inability to perform the breathing manoeuvre needed for eNose-analysis of exhaled air

Trial design

52 participants in 1 patient group

prolonged neutropenic patients

Description:

patients that will undergo treatment for a hematological malignancy expected to result in grade 4 neutropenia of prolonged duration