Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision

Yangzhou University

Status: Not yet enrolling

Conditions: Pain

Treatments: Drug: Esketamine of Intermittent injection; Drug: Esketamine of single injection

Study type: Interventional

Funder types: Other

Identifiers

NCT05811221

2023-YKL01-（ke11）

Details and patient eligibility

About

To explore the application of different administration modes of esketamine in pediatric day circumcision, in order to find an anesthesia scheme more suitable for day pediatric circumcision.

Full description

The current clinical study believes that esketamine is suitable for pediatric anesthesia because of its advantages of light respiratory depression, low secretions, low incidence of psychomotor reactions and fast recovery of anesthesia, but there are few related studies on its administration mode and timing in clinical application, this study aims to explore the application of different administration methods of esketamine in pediatric day circumcision, and find an anesthesia scheme more suitable for day circumcision, in order to provide new ideas for anesthesia for pediatric day circumcision.

Enrollment: 70 estimated patients

Sex: Male

Ages: 6 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) class I and II children
• Age 5-12 years
• Foreskin cerclage is proposed
• No history of upper respiratory tract infection in the past two weeks
• Obtain the consent of the child's family

Exclusion criteria

• Hepatic and renal insufficiency, coagulation dysfunction
• Those who are allergic to esketamine
• History of cognitive impairment
• epilepsy
• other psychiatric and neurological disorders

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups

single group

Active Comparator group

Description:

give esketamine 0.75 mg/kg at the time of induction

Treatment:

Drug: Esketamine of single injection

intermittent group

Experimental group

Description:

give esketamine 0.5mg/kg during anesthesia induction, and during the measuring ring esketamine 0.25mg/kg was given again

Treatment:

Drug: Esketamine of Intermittent injection