Application of Early Goal-directed Sedation in Patients With Severe Brain Injury

Zhejiang University

Status: Completed

Conditions: Brain Injuries, Traumatic

Treatments: Other: Early goal-directed sedation programs

Study type: Interventional

Funder types: Other

Identifiers

NCT04525482

2017-081

Details and patient eligibility

About

EGDS management strategy was implemented in ICU patients with severe brain injury, the depth of sedation and GCS score were monitored, and the protective effects of EGDS strategy and standard sedation strategy on the brain of patients with severe brain injury were discussed.

Enrollment: 300 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of severe craniocerebral injury
• The GCS score is 6 to 12 points
• Within 12 hours of intubation
• The mechanical ventilation time is greater than 24 hours
• Obtain written consent

Exclusion criteria

• Pregnant women
• Acute liver failure
• Dementia or mental illness

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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300 participants in 2 patient groups

Control Group

No Intervention group

Description:

No intervention was implemented

Intervention Group

Experimental group

Description:

Early goal-directed sedation programs was implemented

Treatment:

Other: Early goal-directed sedation programs