Application of Enteral Nutrition Program in Patients With Intra-abdominal Hypertension Oriented by Intra-abdominal Pressure

Zhejiang University

Status

Completed

Conditions

Intra-Abdominal Hypertension

Treatments

Behavioral: enteral nutrition program for patients with abdominal hypertension guided by abdominal pressure

Study type

Interventional

Funder types

Other

Identifiers

NCT05732545

2021-0899

Details and patient eligibility

About

In this study, relevant contents of the enteral nutrition nursing programs for severe patients with abdominal pressure were systematically searched, and quality evaluation was carried out based on existing evidence. Based on evidence-based evidence, an enteral nutrition nursing program for patients with abdominal pressure was constructed, to improve the feed tolerance of patients with abdominal pressure, increase nutritional compliance rate, and improve patient prognosis.

Full description

Background: Enteral nutrition is the preferred method of artificial nutrition for critically ill patients. Early enteral nutrition within 24 to 48 hours after admission can maintain intestinal mucosal barrier function, increase local blood flow, reduce bacterial migration, and reduce the incidence of intestinal infections. Increased abdominal pressure is considered to be an independent risk factor for feeding intolerance in severe patients. Patients with abdominal pressure are prone to complications such as diarrhea, abdominal distension, vomiting, and even aspiration, which forces the suspension or suspension of enteral nutrition and leads to insufficient nutritional intake in patients. At present, there is evidence that regulating enteral nutrition through monitoring intra-abdominal pressure can effectively reduce the incidence of feeding intolerance in patients. Domestic and foreign scholars have formulated nutrition management programs for patients with intra-abdominal pressure from different aspects, such as monitoring and grading of intra-abdominal pressure, evaluation and management of tolerance, and prevention of complications. However, The standardized enteral nutrition feeding program oriented by the monitoring of intra-abdominal pressure has not yet formed a unified standard.

Objective: This study conducted a quality evaluation based on existing evidence, adopted evidence-based research methods to establish an enteral nutrition program for patients with abdominal hypertension oriented by abdominal pressure, and aimed to improve the feeding tolerance of patients with abdominal hypertension, improve the nutritional compliance rate and improve the prognosis of patients through the implementation of evidence-based practice programs.

Enrollment

218 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria
1. 12mmHg≤ intraperitoneal pressure ≤20mmHg (1mmHg=0.133kPa)
2. ≥18 years of age
3. Consistent with the indications of early enteral nutrition
  - Patients with nutritional risk, gastrointestinal function, or partial gastrointestinal function and unable to eat through the mouth
    - Stable hemodynamics (MAP > 65mmHg, blood lactic acid < 4mmol/L, and vasoactive drugs in the process of reduction or withdrawal)
4. Patients or their family members sign the informed consent
Exclusion Criteria
1. Pregnant or lactating female patients
2. Patients with recent abdominal surgery
3. Patients with a large number of abdominal effusions;
4. There are contraindications to enteral nutrition
  - Uncontrolled shock
    - Uncontrolled hypoxemia and acidosis
      - Uncontrolled upper gastrointestinal bleeding
        
        GRV > 500mL/ 6h
        
        Intestinal ischemia
        
        Intestinal obstruction
        
        Abdominal space syndrome (ACS)
        
        High fistula without distal feeding