Application of Growth Factors Derived From Platelets to Accelerate Healing and Reduce Post-extraction Complications in Diabetic Individuals

King Abdulaziz University

Status: Invitation-only

Conditions: Diabete Mellitus

Treatments: Procedure: Platelet rich fibrin

Study type: Interventional

Funder types: Other

Identifiers

NCT07287475

264-12-23

Details and patient eligibility

About

To evaluate soft tissue closure in diabetic extraction sockets using digital scans.

To compare healing between sockets treated with Advanced Platelet Rich Fibrin (A-PRF) vs. untreated control sites.

To assess post-operative discomfort and patient satisfaction.

Enrollment: 12 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Eighteen years or older
• Need bilateral tooth extraction
• Sockets should be the same size
• Diabetic/ uncontrolled
• No other disease
• Non- smoker
• Non-pregnant or lactating female

Exclusion criteria

• Patients below 18 years
• Patients with diseases different from diabetes
• Bleeding disorders
• Pregnancy
• Lactation,
• Tobacco use (conventional or electronic)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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12 participants in 2 patient groups

iPRF

Other group

Description:

Experimental: A- PRF in Extraction sockets in Diabetic patients. Arm Description: A randomized, double-blinded, split-mouth clinical trial was conducted at King Abdulaziz University Dental Hospital. Diabetic patients requiring bilateral extraction of the same tooth were enrolled. One socket was randomly assigned to receive A-PRF while the contralateral socket served as the control. Healing was assessed using digital intraoral scanning at baseline, 1 week, and 2 weeks post-extraction.

Treatment:

Procedure: Platelet rich fibrin

Control

No Intervention group

Description:

Nothing was placed in the socket