Application of Guidelines for Medico-professional Supervision of Workers Exposed to Carcinogenic Action of Wood Dust: CERBois Cohort

Central Hospital, Nancy, France

Status: Completed

Conditions: Exposition to Wood Dust

Treatments: Procedure: Nasofibroscopy

Study type: Observational

Funder types: Other

Identifiers

NCT02884232

2011/INCA/CERBOIS/PARIS-HERIN

Details and patient eligibility

About

The purpose is to evaluate feasibility of medical supervision of professionally active asymptomatic wood workers with questionnaires and nasofibroscopy.

Secondary purposes are:

• Feasibility evaluation of identification of former and actual professional expositions to wood dust and to various naso-sinusal carcinogenics in case of co-expositions (formaldehyde, chrome, nickel, leather)
• Description of abnormal symptoms identified by occupational doctor and needing an otorhinolaryngology test
• Description of results and examinations induced by nasofibroscopy in symptomatic or asymptomatic individuals: counting of naso-sinusal adenocarcinoma cases
• Evaluation of participation of workers retiring in 2 years after inclusion to medical supervision program
• Evaluation of information flow among different players
• Assessment of costs induced by this targeted screening: direct medical costs (screened pathologies, induced additional examinations...) and indirect costs for company (duration of worker absence for transfer, medical and additional examinations).

Enrollment: 800 patients

Sex: All

Ages: 44+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Employee or craftsman
• Actual or former professional exposition to wood dust
• Onset of exposition to wood dust back to more than 30 years (latency >30 years)
• Cumulated exposition to wood dust longer than 12 months
• Exposition to wood dust during machining tasks (sawing, milling, planing, drilling, bridging) or all documented activities exposing to wood dust concentration > 1 mg/m3 for 8 hours
• Worker followed by occupational doctor of participant occupational health departments
• Worker accepting medico-professional supervision recommended by guidelines
• Affiliation to social security

Exclusion criteria

• Difficulty with comprehension of wood auto-questionnaire

Trial design

800 participants in 1 patient group

Workers exposed to wood dust

Treatment:

Procedure: Nasofibroscopy