Application of Hyaluronic Acid in Diabetes

Cairo University (CU)

Status: Enrolling

Conditions: Periodontal Diseases

Treatments: Drug: Hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT05543434

Reem

Details and patient eligibility

About

sub gingival application of hyaluronic acid create great clinical improvement of periodontal pocket treatment.

Full description

To clinically and radiographically evaluate the adjunctive effect of the local application of a 0.8% hyaluronan gel in addition to scaling and root planing in treatment of controlled diabetic patients with stage II periodontitis.

Enrollment: 26 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years.
• Patient with controlled diabetic type 2 (HgA1C <7) (Mori et al., 2021).
• Periodontitis stage II.
• Periodontitis grade B.
• Pocket depth > 4 mm.
• Smoking ≤ 10 cigarettes/day.
• Cooperative patients able and accept to come for follow up appointments

Exclusion criteria

• • The use of antibiotics or anti-inflammatory drugs 1 month prior to the procedure and till the end of 6 months of follow-up.

  • Having surgical therapy or undergoing orthodontic treatment.
  • Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis.
  • Pregnant and lactation females.
  • Smoking ˃ 10 cigarettes/day.
  • Patients with poor oral hygiene.
  • Any known allergies

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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26 participants in 2 patient groups

hyaluronic acid

Experimental group

Description:

Application of crosslinked HA gel in pockets after subgingival debridement immediately and one week after.

Treatment:

Drug: Hyaluronic acid

scaling and root planing

Active Comparator group

Description:

scaling and root planing using ultrasonic scaler and hand instruments.

Treatment:

Drug: Hyaluronic acid