Application of in Vivo Splitting Technique in Adult Liver Transplantation

Ningbo Medical Center Lihuili Hospital

Status: Active, not recruiting

Conditions: Liver Transplantation

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06925828

CT2025-LHL-OBS1

Details and patient eligibility

About

The feasibility of split liver transplantation (SLT) remains controversial. This study aimed to evaluate the outcomes of SLT in adult recipients and to identify specific areas of improvements. A retrospective analysis was conducted on adults who underwent full size SLT between January 2021 and December 2023. The short-term outcomes of these patients who underwent SLT were compared with those of patients who underwent whole liver transplantation (WLT) during the same period.

Enrollment: 500 patients

Sex: All

Ages: 16 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• For the donor graft:

  1. age of 18-60 years;
  2. BMI of 19-28 kg/m2;
  3. hemodynamic stability or use of a single vasoactive drug with a small dosage (norepinephrine ≤ 0.1 μg/kg/min or dopamine ≤ 5 μg/kg/min);
  4. liver steatosis ≤ 10%;
  5. liver functional indicators (ALT, AST, total bilirubin quantification) ≤ 3 times the normal value;
  6. blood sodium ≤ 160 mmol/L;

For the SLT recipients

1. Patients who had registered in the China Organ Transplant Response Systems.
2. Initial liver transplantation.
3. Graft-to-Recipient Weight Ratio (GRWR) ≥ 1%.

Exclusion criteria

• For the donor graft

  1. uncontrollable infection
  2. significant vascular and biliary variation.

For the recipients

1. Severe portal hypertension.
2. Significant vascular variation.

Trial design

500 participants in 2 patient groups

SLT group

Description:

Adult recipients who underwent split liver transplantation

Treatment:

Other: No intervention

WLT group

Description:

Adult recipients who underwent whole liver transplantation

Treatment:

Other: No intervention