Application of Integrated MR-PET in Patients With Gynecologic Cancers

National Taiwan University

Status: Unknown

Conditions: MR-PET Imaging

Treatments: Other: Medical Imaging

Study type: Observational

Funder types: Other

Identifiers

NCT02292615

201402075MIND

Details and patient eligibility

About

In this prospective cohort study, patients with newly diagnosed gynecologic cancers (including cervical, endometrial, and ovarian cancers) and patients with suspicious recurrent gynecologic cancers will be enrolled. The study period is two years and the estimated patient number is about 220. Patients will undergo image study before and after treatment. The diagnostic accuracy of MR-PET in cancer staging and the potential image biomarkers to monitor treatment response and predict treatment outcome will be investigated.

Enrollment: 220 estimated patients

Sex: Female

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Group 1: Patients with newly diagnosed gynecologic cancers (including cervical, endometrial, and ovarian cancers).
2. Group 2: Patients with suspicious recurrent gynecologic cancers (including cervical, endometrial, and ovarian cancers).
3. Group 3: Patients with ovarian cancer who had debulking surgery and are going to receive adjuvant chemotherapy.

Exclusion criteria

1. Age <20 or >90 years old
2. Contraindication for MRI:
3. Contraindication for MR contrast medium (Cre > 2.0)
4. History of other malignancy
5. Prior arthroplasty of hip or pelvic bone surgery with metallic fixation (may cause artifacts on MRI)
6. Pregnant or lactating women

Trial design

220 participants in 3 patient groups

cervical cancer

Description:

Group 1: Patients with newly diagnosed gynecologic cancers (including cervical, endometrial, and ovarian cancers).

Treatment:

Other: Medical Imaging

endometrial cancer

Description:

Group 2: Patients with suspicious recurrent gynecologic cancers (including cervical, endometrial, and ovarian cancers).

Treatment:

Other: Medical Imaging

ovarian cancer

Description:

Group 3: Patients with ovarian cancer who had debulking surgery and are going to receive adjuvant chemotherapy.

Treatment:

Other: Medical Imaging