Application of Intrahepatic Arterial Infusion Chemotherapy for Patients With High Risk of Liver Metastases After Pancreatic Cancer Surgery

Peking University

Status: Unknown

Conditions: Who Have High CTCs Count in Portal Venous Blood; Liver Metastases; Pancreatic Ductal Adenocarcinoma

Treatments: Device: Intrahepatic Arterial Infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT03687853

HAI PDCA 1.0

Details and patient eligibility

About

Clinical results on intra-arterial adjuvant chemotherapy for prevention

of liver metastasis following curative resection of pancreatic cancer

Full description

In this study, the investigator try to select 80 patients who received radical surgery for pancreatic cancer, whose circulating tumor cells(CTCs) count then performed on intraoperative portal venous blood to predict postoperative liver metastasis and were divided into two groups. for those who have high CTCs count may have more chance for the occurrence of postoperative liver metastasis was applied hepatic arterial perfusion chemotherapy with minimal dynamic randomization. The aim is to evaluate the feasibility of hepatic arterial infusion chemotherapy for the prevention of postoperative liver metastasis and improvement of prognosis of pancreatic cancer, so as to further improve postoperative management of pancreatic cancer

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pancreatic cancer patients who received the radical operation

Exclusion criteria

• who accepted chemotherapy before operation or who cannot or do not will to accepted enrolled into this study

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Intrahepatic Arterial Infusion chemotherapy

Experimental group

Description:

chemotherapy through intrahepatic arterial Infusion is one of the most widely used liver tumor treatments.

Treatment:

Device: Intrahepatic Arterial Infusion

control

No Intervention group

Description:

chemotherapy through Peripheral venous is one of the regularly used method.