Application of Magnetic Resonance Fat-Free Imaging

Memorial Sloan Kettering Cancer Center (MSK)

Status: Terminated

Conditions: Sarcoma

Treatments: Procedure: Fat-free MRI images utilizing standard magnetization, Questionnaire before the MRI exam

Study type: Observational

Funder types: Other

Identifiers

NCT00944476

09-078

Details and patient eligibility

About

Magnetic resonance imaging (MRI) is presently the best study for assessing the size and extent of the patient's sarcoma. Many sarcomas contain fat that can interfere with the accuracy of sarcoma detection. The investigators have developed a new MRI method that can suppress all the fat signals in the patient's tumor and this may improve the investigators' ability to see the patient's sarcoma. The purpose of this study is to determine if the investigators' new fat-free imaging methods provides them with images that are better than, equal to, or worse than those images obtained by standard MRI methods. This study may help the investigators develop a more accurate MRI examination.

Full description

In addition, we will perform the same scans on 4 volunteers who have no history of sarcoma. Scanning volunteers will allow us to optimize the imaging technique by 1.) Determine the best combination of pulse-sequence and magnetization transfer technique to obtain the greatest contrast and 2.) Determine the parameters of repetition time (TR), echo time (TE) and magnetization transfer time and power in order to reduce overall image acquisition time while optimizing image quality. Honing this technique on volunteers will allow us to decrease scan time and potential discomfort for patients.

Enrollment: 2 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Participant is capable of providing verbal consent.
• 18 years of age or older.
• Participants will belong to one of the following two categories:
• Patient with a known or suspected soft tissue sarcoma of the extremity or trunk who is/will be scheduled for an MRI scan as part of their routine care, -OR--
• Volunteer with no history of sarcoma.

Trial design

2 participants in 1 patient group

Pts/volunteers getting regular MRI exam

Description:

Fat-free MRI images utilizing standard magnetization transfer imaging will be acquired on 10 patients known or suspected sarcoma of the of the extremity or trunk, in addition to their traditional clinical MRI. In addition, we will perform the same scans on 4 volunteers who have no history of sarcoma.

Treatment:

Procedure: Fat-free MRI images utilizing standard magnetization, Questionnaire before the MRI exam