Application of Plant Protection Products (PPP) in Apple Orchards (aPPPle)

German Federal Institute for Risk Assessment

Status: Enrolling

Conditions: Dermal Exposure; Metabolites in Urine; Effekt Biomarker in Blood; Inhalative Exposure

Study type: Observational

Funder types: Other

Identifiers

NCT06884189

02

Details and patient eligibility

About

The aim of the aPPPle pilot study is to test feasibility and generate first results in preparation for a main study. The aPPPle study will investigate the exposure of operators, workers and residents to plant protection products (PPP) and potential physiological effects on blood biomarkers. The target plants are apple crops, as application occurs at higher altitudes and therefore higher drift/exposure is expected compared to ground-level application. The substances to be investigated are acetamiprid (an insecticide) and dithianon and dodine (two fungicides).

Enrollment: 16 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• belonging to one of the defined study groups
• over 18 years of age at the time of recruitment
• person can understand the language and content of the study requirements
• person is capable of consenting to participate in the study and has given written consent to participate in the aPPPle study
• person has health insurance

Exclusion Criteria for residents and control:

person has direct professional contact with the tested substances acetamiprid, dithianon or dodine

Trial design

16 participants in 4 patient groups

Operators

Description:

People who apply plant protection products to apple crops.

Workers

Description:

People who do manual work in apple cultivation, like pruning or harvesting.

Residents

Description:

People whose place of residence is adjacent to the orchard under investigation.

Control

Description:

People whose place of residence is at least 10 km away from agricultural apple orchards and a maximum of 150 km away from the apple orchard under investigation.