Application of the Propofol Precise Infusion Model

Sichuan University

Status: Completed

Conditions: Propofol Overdose of Undetermined Intent

Treatments: Drug: Propofol

Study type: Observational

Funder types: Other

Identifiers

NCT05158426

WestChinaH-2018-1

Details and patient eligibility

About

Propofol is one of the most commonly used anesthetics in the world. However, the dose-response of propofol was remarkable variety. Herein, this study aims to investigate the possible association of gene polymorphism and propofol susceptibility, and to research more precise infusion model of this drug.

Full description

Patients undergoing gastrointestinal endoscopy will be recruited. Anesthesia is induced with propofol via TCI at 1.5µg/ml, and increases 0.5µg/ml for every 3min until OAA/S score 0. During this period, OAA/S score will be evaluated every 1min until OAA/S score 0. At this moment, the blood concentration of propofol, the doses of propofol, the onset time and BIS are recorded, and blood sample for gene polymorphism detection were required.

Enrollment: 400 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients who undergoing gastrointestinal endoscopy with anesthesia
2. age ≥18 years

Exclusion criteria

1. hepatic or kidney function injured;
2. received hypnotic sedative drug regularly;
3. Pregnancy, excessive drinking, or current smoker;
4. be allergic to propofol
5. patients who with difficulty communication

Trial design

400 participants in 1 patient group

propofol susceptibility group

Description:

patients undergoing gastrointestinal endoscopy

Treatment:

Drug: Propofol