Application of Transcranial Direct Current Stimulation (tDCS) for Gait Function Improvement of Parkinson's Disease Patient

Samsung Medical Center

Status: Completed

Conditions: Parkinson Disease

Treatments: Device: Brain stimulation; Device: Treadmill gait training

Study type: Interventional

Funder types: Other

Identifiers

NCT04591236

2020-09-093

Details and patient eligibility

About

The purpose of this study was to investigate the effect of simultaneous application of transcranial direct current stimulation (tDCS) and treadmill gait training for gait function recovery in Parkinson's disease patients with gait impairment.

Enrollment: 24 patients

Sex: All

Ages: 50 to 74 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: 50 - 75 years
• Modified Hoehn and Yahr stages 1 to 4

Exclusion criteria

• Serious cardiac conditions (hospitalization for myocardial infarction or heart surgery within 3 months, history of congestive heart failure, documented serious and unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living)
• Difficult to understand experimental tasks because of extremely severe cognitive impairment (Korean-Mini-Mental State Examination, K-MMSE≤10)
• History of psychiatric disease
• Implanted objects that would contraindicate tDCS

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

Gait training with brain stimulation

Experimental group

Description:

Treadmill gait training and transcranial direct current stimulation (tDCS) on the leg motor areas

Treatment:

Device: Brain stimulation

Device: Treadmill gait training

Gait training with sham brain stimulation

Active Comparator group

Description:

Treadmill gait training and anodal sham transcranial direct current stimulation (tDCS) on the leg motor areas

Treatment:

Device: Treadmill gait training