Application of Two Different Synthetic Sequential Media for the Human IVF-Embryo Transfer (IVF-ET) Program

Maria Fertility Hospital

Status: Completed

Conditions: Infertility

Treatments: Other: Sydney IVF media; Other: MRC media

Study type: Interventional

Funder types: Other

Identifiers

NCT01356238

MRC-1

Details and patient eligibility

About

Quality-controlled commercial media have been used in many in-vitro fertilization (IVF) laboratories. However, commercial media are costly and difficult to compare directly because their exact compositions are not clearly indicated. Although commercially available media have commonly been used in most IVF programs worldwide, there are several advantages to the use of in-house synthetic sequential media at IVF laboratories. First, the results of quality control should be reliable due to a stringent protocol setting-up. Second, any direct supplementations or deletions of specific components are feasible to obtain good quality embryos and high pregnancy rates since those components can be defined. Finally, dependence on commercially available media diminishes so that the laboratory can more easily accommodate unexpected situations or problems, such as a sudden increase in IVF patients. Therefore, the present study was conducted to compare the efficacy of in-house MRC media in the human IVF-embryo transfer (ET) program to that of commercially available media.

Enrollment: 360 patients

Sex: Female

Ages: 20 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing IVF treatment in our clinic during study period

Exclusion criteria

• Females older than 40 years
• Patients showed fertilization failure
• Patients with less than two 2PN embryos

Trial design

360 participants in 2 patient groups

MRC media

Experimental group

Description:

Use MRC media in the human IVF-ET program

Treatment:

Other: MRC media

Sydney IVF media

Active Comparator group

Description:

Use Sydney IVF media in the human IVF-ET program

Treatment:

Other: Sydney IVF media