Applications of MRI in Kidney Disease

University of Minnesota (UMN)

Status: Withdrawn

Conditions: Chronic Kidney Disease; End-stage Kidney Disease

Treatments: Other: No intervention but only observational

Study type: Observational

Funder types: Other

Identifiers

NCT02832505

1603M85321

Details and patient eligibility

About

This study has two major purposes:

1. To test developed multiple anatomic and functional MRI methods;
2. To evaluate the potentials of these MRI methods in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction.

These purposes will be achieved by performing pilot studies with cohorts of patients.

Full description

This study is observational with no intervention applied for the patients. In this study, multiple anatomic and functional MRI methods will be performed with three cohorts of patients. In addition to anatomic MRI methods, non-contrast enhanced functional MRI methods will also be applied to evaluate tissue perfusion and vascular reactivity in these patients.

Sex: All

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. English-speaking as primary language
2. Able to complete an approximately 75 to 90 minute cognitive and/or physical tests
3. Capable to consent to studies

Exclusion criteria

1. Acute psychiatric illness that would impede cognitive testing
2. Active chemical dependence, such as alcohol, narcotics or other drugs
3. Legally blind or unable to complete cognitive tests due to visual loss or deafness
4. Renal transplant recipient at time of screening or baseline
5. Severe CI unable to complete the Modified Mini-Mental State Examination [3MSE]
6. Chronic and acute pulmonary disease

Trial design

0 participants in 3 patient groups

Non-CKD (Control)

Description:

Patients without CKD (eGFR ≥ 60 ml/min/1.73 mm2) (non-CKD controls). No intervention but only observational.

Treatment:

Other: No intervention but only observational

CKD (chronic kidney disease)

Description:

Patients with Patients with moderate to severe CKD (eGFR ranging from 26 to 44 ml/min/1.73 mm2). No intervention but only observational.

Treatment:

Other: No intervention but only observational

ESRD (end-stage renal disease)

Description:

Patients with advanced CKD (eGFR \< 15 ml/min/1.73 mm2), preparing for or undergoing the standard thrice-weekly HD or standard PD treatment (end-stage renal disease (ESRD) patients). No intervention but only observational.

Treatment:

Other: No intervention but only observational