Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With MCI

The Third Central Clinical College of Tianjin Medical University

Status: Unknown

Conditions: Cognitive Impairment, Mild

Treatments: Drug: Sevoflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03165396

szxlcyj-chen

Details and patient eligibility

About

According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups. The different combinations of propofol and sevoflurane were used in the four groups: 1 day before surgery, after patients become wide-awake, and 3 days, 7 days, and 3 months after surgery, the patient's cognitive function was evaluated using a professional cognitive scale and other indicators. Finally, statistical analysis.

Enrollment: 100 estimated patients

Sex: All

Ages: 50 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Elective orthopaedic surgery
• American Society of Anesthesiologists physical status: II

Exclusion criteria

• Neurological diseases that may affect cognitive function (e.g., subdural hematoma)
• Hypothyroidism
• Alcoholic dementia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 4 patient groups

Propofol

Experimental group

Description:

administrated Target Controlled Infusion （TCI）of propofol （Cp 2.0\~2.5μg/ml ）for maintaining

Treatment:

Drug: Propofol

1.2 μg/ml Propofol

Experimental group

Description:

administrated Target Controlled Infusion （TCI）of propofol （Cp 1.2 μg/ml ）combined with appropriate sevoflurane for maintaining

Treatment:

Drug: Sevoflurane

Drug: Propofol

0.6 μg/ml Propofol

Experimental group

Description:

administrated Target Controlled Infusion （TCI）of propofol （Cp 0.6 μg/ml ）combined with appropriate sevoflurane for maintaining

Treatment:

Drug: Sevoflurane

Drug: Propofol

Sevoflurane

Experimental group

Description:

administrated 1.3 minimum alveolar concentration（MAC ） sevoflurane for maintaining

Treatment:

Drug: Sevoflurane