AQP-1 Polymorphism on Fluid Status in Hemodialysis Patients

Shanghai Jiao Tong University

Status: Not yet enrolling

Conditions: End Stage Renal Disease on Dialysis

Treatments: Other: observational study, no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05275387

KY2021-149-B

Details and patient eligibility

About

It is a cross sectional observational study. It is to investigate whether AQP-1 polymorphism has any impact on fluid status in hemodialysis patients. The long term stable HD patients in the current center will be enrolled to the study after informed consent. Blood samples will be collected for gene-typing. Fluid status including blood pressure, weekly UF and intra-dialysis body weight change will be collected through their clinical records.

Enrollment: 250 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-70
• ESRD
• maintained HD
• no target weight change during the last week of entering the study and achieve target weight at the end of HD section
• informed consented

Exclusion criteria

• expected survival time less than 3 months