Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution (Whistler)

NicOx

Status and phase: Completed; Phase 3; Phase 2

Conditions: Open Angle Glaucoma

Treatments: Drug: Placebo; Drug: NCX 470

Study type: Interventional

Funder types: Industry

Identifiers

NCT05938699

NCX 470-05

Details and patient eligibility

About

This is a double-masked, placebo-controlled study which will determine the action of NCX 470 ophthalmic solution, 0.1% on aqueous humor dynamic parameters in healthy volunteers or subjects with OHT.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. ≥18 years of age
2. Either gender
3. Subjects without glaucoma
4. Qualifying IOP at Screening Visit

Exclusion criteria

1. Narrow anterior chamber angles or disqualifying central corneal thickness in either eye
2. Clinically significant ocular disease in either eye
3. Uncontrolled systemic disease
4. Serious hypersensitivity to topical anesthetic eye drops
5. Subjects with a known hypersensitivity or contraindications to any of the ingredients in the study medications

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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18 participants in 2 patient groups, including a placebo group

NCX 470 0.1%

Active Comparator group

Description:

NCX 470 0.1% - one drop in the randomized eye once a day for 8 days

Treatment:

Drug: NCX 470

Placebo

Placebo Comparator group

Description:

Artificial tears - one drop in the randomized eye once a day for 8 days

Treatment:

Drug: Placebo