Aqueous Humor Proteome in Retinal Vein Occlusion With Macular Edema

Tianjin Medical University Eye Hospital

Status

Active, not recruiting

Conditions

Retinal Vein Occlusion

Study type

Observational

Funder types

Other

Identifiers

NCT07106268

MR-12-24-035937

Details and patient eligibility

About

the goal of this observational study is to the find the molecular mechanisms underlying the prognosis process of Retinal vein occlusion in patients with retinal vein occlusion . The main question it aims to answer is:

What are the changes in protein in the aqueous humor during treatment in patients who are sensitive to anti-VEGF drug therapy?

Enrollment

100 estimated patients

Sex

All

Ages

20 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Cystic or diffuse edema in the macular area, retinal vein tortuous dilation with hemorrhage
Optical coherence tomography (OCT) examination showed that the macular area was raised, edema and thickened
Monocular disease, baseline central retinal thickness (CRT) ≥ 250mm
Intravitreal injection, laser photocoagulation and blood circulation and blood stasis removal drugs were not treated before surgery
The patient had normal blood pressure, negative urine protein, normal liver and kidney function, and normal electrocardiogram

Exclusion criteria

Patients with fluorescein fundus angiography (FFA) showing a large area (10 optic disc areas) without perfusion requiring retinal photocoagulation
Patients with chronic dacryocystitis, glaucoma, cataract, severe proliferative vitreoretinopathy or vitreous hemorrhage, epi macular membrane or macular ischemia, diabetic retinopathy, age-related macular degeneration, ocular trauma and other diseases
Intravitreal therapy or laser photocoagulation with corticosteroids or anti-VEGF drugs within three months before the study