Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients (MASCADI)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Carotid Stenosis

Treatments: Procedure: blood samples; Procedure: recover samples of atheromatous plaque

Study type: Observational

Funder types: Other

Identifiers

NCT03202823

MENEGAUT 2016

Details and patient eligibility

About

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

Enrollment: 204 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have provided explicit consent
• Patients older than 18 years
• Patients about to undergo surgery for carotid stenosis
• Haemoglobin ≥ 7g/dl at the time the sample is taken
• Respect the maximum volume of blood taken (treatment + research) in 30 days

SPECIFIC TO DIABETICS

• Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier

Exclusion criteria

• Patients under guardianship
• Patients without health insurance cover
• Pregnant or breast-feeding women

Trial design

204 participants in 2 patient groups

Diabetics

Treatment:

Procedure: blood samples

Procedure: recover samples of atheromatous plaque

Non-diabetics

Treatment:

Procedure: blood samples

Procedure: recover samples of atheromatous plaque