ARCHIPELAGO: Irbesartan in Patients With Acute Coronary Syndrome Without ST Segment Elevation

Sanofi

Status and phase

Completed

Phase 3

Conditions

Hypertension

Myocardial Ischemia

Treatments

Drug: Irbesartan

Study type

Interventional

Funder types

Industry

Identifiers

NCT00296218

PM_C_0024

EudraCT #: 2005-002161-36

Details and patient eligibility

About

Primary Objective

The main objective of this study is to assess if a two-month regimen of irbesartan in patients hospitalized for acute coronary syndrome without ST segment elevation can reduce inflammation markers (ie hsCRP), in comparison to a similar regimen of enalapril.

Secondary Objectives

To compare both regimens on several other biological parameters which have demonstrated their relevance and their predictive clinical value (ie BNP, microalbuminuria, troponin I ...) in this patient population.
To compare on the above parameters the early initiation of treatment versus the initiation of treatment at hospital discharge.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

The following information on clinical trials is provided for information purposes only to allow patients and physicians to have an initial discussion about the trial. This information is not intended to be complete information about the trial, to contain all considerations that may be relevant to potential participation in the trial, or to replace the advice of a personal physician or health professional.

Main criteria are listed hereafter:

Inclusion Criteria

Patient hospitalised with ischemic symptoms (last episode within the last 48 hours before randomization) and at least one of the following characteristics of NSTEACS (non-ST-segment-elevation acute coronary syndromes):
- ECG ST or T changes (ST depression or transient elevation of at least 1mm or T wave changes in at least 2 leads)
- Positive troponin (according to local threshold)

Exclusion Criteria

Women of child bearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for up to 4 weeks after the study WOCBP using a prohibited contraceptive method (not applicable)
Women who are pregnant or breast feeding
Women with a positive pregnancy test on enrolment or prior to study drug administration
Patient with dementia
Persistent ST segment elevation at ECG
Systolic blood pressure < 100 mmHg
Bilateral stenosis of renal artery
Creatinine clearance < or = 30ml/mn
Congestive heart failure with symptoms consistent with New York Heart Association (NYHA) class III or IV.
Aortic or mitral valve stenosis
Hypertrophic cardiomyopathy
Connective tissue disease with vascular involvement
Angioplasty, surgery or trauma within the last 3 months
Coronarography or angioplasty planned to be performed or performed before baseline sampling
Febrile (≥ 38°C) disease, known concomitant viral or bacterial infection, chronic auto immune disease, chronic inflammatory disease, known cancer in evolution
Hyperkalemia: serum potassium > 5.5mmol/l
Sensitivity or intolerance to Angiotensin receptor blockers (ARBs) : olmesartan, candesartan, irbesartan, eprosartan, losartan, telmisartan, valsartan and/or any other ARB currently or previously in development.
Sensitivity or intolerance to Angiotensin-converting Enzyme Inhibitors (ACE-I) : benazepril, captopril, enalapril, lisinopril, trandolapril, ramipril, quinapril, and/or any other ACE-I currently or previously in development.
Chronic steroid or non-steroidal anti inflammatory drugs (NSAIDs) use. Aspirin is permitted.
Treatment with allopurinol or procaïnamide
Concomitant use of potassium sparing diuretics (eg. spironolactone, triamterene or amiloride), potassium preparations or salt substitutes containing potassium
Treatment with Lithium
Immunosupressive medication
Administration of any other investigational drug in the last 30 days before enrolment and during the course of the study
Treatment with ARB or ACE inhibitor within the last 3 days.