Are Sporadic Colorectal Cancers in Young Distinct From Elderly?

Seoul National University

Status: Completed

Conditions: Colorectal Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT05601609

B-2011/651-103

Details and patient eligibility

About

In this study, the investigators compared and evaluated the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) in young adults without genetic mutations associated with hereditary CRC syndrome and sporadic CRC in elderly individuals.

Full description

The ambiguity in the findings among several previous studies might be because of the difference in the age of the study population, yCRC and eCRC. The family history of CRC and cancer due to Crohn's disease or ulcerative colitis were also not excluded in such previous studies. Most importantly, those studies did not rule out the risk of hereditary cancer through the genetic testing in yCRC. Since hereditary CRC accounts for approximately 34% of those under the age of 35 years, it is necessary to exclude it to accurately compare the clinicopathological characteristics of sporadic cancer developed in yCRC and eCRC.

Enrollment: 1,599 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically confirmed cases of adenocarcinoma in the colon and rectum
• The age at the time of diagnosis should be ≤ 40 years (for yCRC) or ≥ 70 years (for eCRC)
• Genetic testing confirmation of non-hereditary cancer.

Exclusion criteria

• Inflammatory bowel disease
• A family history of CRC
• A history of other cancers
• Underwent any emergency operation or palliative surgery
• The Amsterdam criteria with mutations in genes associated with APC, MLH1, MSH2, MSH6

Trial design

1,599 participants in 2 patient groups

young colorectal cancer (yCRC)

Description:

1. histologically confirmed cases of adenocarcinoma in the colon and rectum 2. the age at the time of diagnosis should be ≤ 40 years

elderly colorectal cancer (eCRC)

Description:

1. histologically confirmed cases of adenocarcinoma in the colon and rectum 2. the age at the time of diagnosis should be ≥ 70 years